Couple suffering most woe (7)
I believe the answer is:
twosome
'couple' is the definition.
(synonyms)
'suffering most woe' is the wordplay.
'suffering' indicates anagramming the letters.
'most'+'woe'='mostwoe'
'mostwoe' is an anagram of 'TWOSOME'.
(Other definitions for twosome that I've seen before include "game of golf" , "Pair, duo" , "Item" , "match" , "Couple" .)