Crazily go insane at seeing needle (10)
I believe the answer is:
antagonise
'needle' is the definition.
(both can mean to provoke or irritate somebody)
'crazily go insane at' is the wordplay.
'crazily' is an anagram indicator.
'go'+'insane'+'at'='goinsaneat'
'goinsaneat' with letters rearranged gives 'ANTAGONISE'.
'seeing' acts as a link.
(Other definitions for antagonise that I've seen before include "Get on the wrong side of" , "anger" , "Bug" , "Cause opposition" , "Arouse hostility" .)