Crazy line-up like wolf? (6)
I believe the answer is:
lupine
'like wolf?' is the definition.
(I know this)
'crazy line-up' is the wordplay.
'crazy' indicates an anagram.
'line-up' becomes 'lineup' (synonyms).
'lineup' anagrammed gives 'LUPINE'.
(Other definitions for lupine that I've seen before include "like a wild animal" , "Of or like wolves" , "Like some ferocious beast" , "Like a wolf" , "Line up (anag)" .)