Create a draught that you could do without? (8)
I believe the answer is:
dispense
'do without?' is the definition.
(I've seen this before)
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for dispense that I've seen before include "Prepare and distribute medicine" , "Enforce (justice)" , "Deal out or distribute" , "Execute" , "Supply (as chemist)" .)