Created in sixes, indeed! (7)
I believe the answer is:
devised
'created' is the definition.
(devising is a kind of creating)
'sixes indeed' is the wordplay.
I cannot really understand how this works, but
'sixes' could be 'vis' ('VI' can be a synonym of 'six') and 'vis' is found within the answer.
The remaining letters 'deed' is a valid word which might be clued in a way I don't understand.
This may be the basis of the clue (or it may be nonsense).
'in' acts as a link.
Can you help me to learn more?
(Other definitions for devised that I've seen before include "Conceived" , "Invented" , "Came up with, a plan say" .)