Creature from Manila (6)
I believe the answer is:
animal
'creature' is the definition.
(I know that creature can be written as animal)
'from manila' is the wordplay.
'from' is an anagram indicator (the anagram comes from the same letters).
'manila' is an anagram of 'ANIMAL'.
(Other definitions for animal that I've seen before include "savage" , "Kind of instinct" , "Mammal" , "One sharing our kingdom" , "Creature having voluntary movement" .)