Crime rate, regrettably, male issue (7)
I believe the answer is:
treason
'crime' is the definition.
(treason is a kind of crime)
'rate regrettably male issue' is the wordplay.
'regrettably' is an anagram indicator.
'male issue' becomes 'son'.
'rate' is an anagram of 'trea'.
'trea'+'son'='TREASON'
(Other definitions for treason that I've seen before include "rebellion" , "Stare on (anag.)" , "attempting to overthrow the king" , "Betrayal of the state" , "Betraying one's country" .)