Cross a new grand railway (5)
I believe the answer is:
angry
'cross' is the definition.
(I've seen this in another clue)
'a new grand railway' is the wordplay.
'new' becomes 'n' (common abbreviation eg NT for New Testament).
'grand' becomes 'g' (G is short for grand as in a thousand).
'railway' becomes 'ry' (abbreviation for railway).
'a'+'n'+'g'+'ry'='ANGRY'
(Other definitions for angry that I've seen before include "In a paddy" , "Furious" , "Incensed" , "Irate, wrathful" , "Vexed" .)