Cry of anguish from an Indian outright! (5)
I believe the answer is:
groan
'cry' is the definition.
(thesaurus)
I don't understand how the remainder of the clue works.
Can you help me to learn more?
(Other definitions for groan that I've seen before include "express disapproval" , "painful sigh" , "Titus -- (Mervyn Peake)" , "Moan, grumble" , "Express disappointment, pain" .)