Cry “shocker”, with house getting overrun initially (6)
I believe the answer is:
boohoo
'cry' is the definition.
(boohoo represents someone crying)
'shocker with house getting overrun initially' is the wordplay.
'shocker' becomes 'boo' (you might say 'boo!' to shock someone).
'with' is a charade indicator (letters next to each other).
'house' becomes 'ho' (abbreviation for house).
'getting' says to put letters next to each other.
'initially' says to take the initial letters.
The initial letter of 'overrun' is 'o'.
'boo'+'ho'+'o'='BOOHOO'
(Other definitions for boohoo that I've seen before include "Colloquially, weep noisily" , "Lamentation" , "Sob convulsively" , "Sound of noisy crying" , "Sob noisily" .)