Cry with pain (4)
I believe the answer is:
wail
'cry' is the definition.
(wailing is a kind of crying)
'with pain' is the wordplay.
'with' becomes 'w' (abbreviation).
'pain' becomes 'ail' ('ail' can be a synonym of 'pain').
'w'+'ail'='WAIL'
(Other definitions for wail that I've seen before include "Utter a long sad cry" , "Lament noisily" , "Cry piteously" , "Sorrowful cry" , "Lament loudly" .)