Cur's resistance to meet animal (6)
I believe the answer is:
rotter
'cur's' is the definition.
(thesaurus)
'resistance to meet animal' is the wordplay.
'resistance' becomes 'r' (abbreviation).
'to meet' means one lot of letters go next to another.
'animal' becomes 'otter' (I've seen this before**).
'r'+'otter'='ROTTER'
(Other definitions for rotter that I've seen before include "Cruel and mean person" , "Rogue" , "Something going off" , "Cad, stinker" , "rat" .)