Damage in rain out at sea (9)
I believe the answer is:
ruination
'damage' is the definition.
(thesaurus)
'in rain out at sea' is the wordplay.
'at sea' is an anagram indicator.
'in'+'rain'+'out'='inrainout'
'inrainout' with letters rearranged gives 'RUINATION'.
(Other definitions for ruination that I've seen before include "Complete destruction or collapse" , "Utter destruction" , "Crippling defeat" , "Complete downfall" , "End" .)