Damage it, amulet suffering (8)
I believe the answer is:
mutilate
'damage' is the definition.
(mutilating is a kind of damaging)
'it amulet suffering' is the wordplay.
'suffering' is an anagram indicator.
'it'+'amulet'='itamulet'
'itamulet' is an anagram of 'MUTILATE'.
(Other definitions for mutilate that I've seen before include "Disarm perhaps" , "Destroy" , "butcher" , "Severely damage" , "9 across (anag)" .)