Daring presumption (5)
I believe the answer is:
nerve
I believe this clue is a double definition.
'daring' is the first definition.
(I've seen this before)
'presumption' is the second definition.
(I've seen this in another clue)
(Other definitions for nerve that I've seen before include "Cord that carries instructions from brain to body" , "Steadiness, courage" , "Fibre that carries instructions to the brain" , "Bodily fibre carrying sensation" , "Valour, pluck" .)