Dark blotches most likely stop skin developing (8)
I believe the answer is:
inkspots
'dark blotches most likely' is the definition.
(inkspots might be dark blotches of ink)
'stop skin developing' is the wordplay.
'developing' is an anagram indicator.
'stop'+'skin'='stopskin'
'stopskin' is an anagram of 'INKSPOTS'.
(Another definition for inkspots that I've seen is " Blotches".)
I've seen this clue in The Times.
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