Daughter has strange instrument (4)
I believe the answer is:
drum
'instrument' is the definition.
(I know that drum is a drum)
'daughter has strange' is the wordplay.
'daughter' becomes 'd' (genealogical abbreviation).
'has' is a charade indicator (letters next to each other).
'strange' becomes 'rum' (synonyms).
'd'+'rum'='DRUM'
(Other definitions for drum that I've seen before include "one will be beaten" , "Large barrel" , "12th" , "Musical instrument" , "house" .)