Daughter with strange percussive instrument (4)
I believe the answer is:
drum
'percussive instrument' is the definition.
(I know that drum is a type of percussive instrument)
'daughter with strange' is the wordplay.
'daughter' becomes 'd' (genealogical abbreviation).
'with' is a charade indicator (letters next to each other).
'strange' becomes 'rum' (synonyms).
'd'+'rum'='DRUM'
(Other definitions for drum that I've seen before include "(Revolving) cylinder" , "house" , "Iris rootstock (perfume)" , "nightclub" , "Large barrel" .)