Dave in an uprising in US state (6)
I believe the answer is:
nevada
'us state' is the definition.
(I know that Nevada is a U.S. state)
'dave in an uprising' is the wordplay.
'in' means one lot of letters goes inside another.
'uprising' says the letters should be written in reverse.
'dave' placed into 'an' is 'adaven'.
'adaven' back-to-front is 'NEVADA'.
'in' acts as a link.
(Other definitions for nevada that I've seen before include "Curiously, Dan and Eva are in the US" , "State of western USA" , "Southwestern US state" , "Arid US state" , "American state, capital Carson City" .)