Dealing with Ike's partner, a bit of a looker (6)
I believe the answer is:
retina
'bit of a looker' is the definition.
(part of an eye, something which looks)
'dealing with ike's partner a' is the wordplay.
'dealing with' becomes 're' (regarding).
'ike's partner' becomes 'tin' (I can't justify this - if you can you should believe this answer much more).
're'+'tin'+'a'='RETINA'
Can you help me to learn more?
(Other definitions for retina that I've seen before include "Part of the eyeball" , "Sensitive part of eye" , "Light-sensitive eye layer" , "Tear in (anag) - part of the eye" , "Sensitive layer in eye" .)