Death, downfall (4)
I believe the answer is:
doom
I believe this clue is a double definition.
'death' is the first definition.
(thesaurus)
'downfall' is the second definition.
(I've seen this before)
(Other definitions for doom that I've seen before include "Unavoidable ill-fortune" , "Death, destruction" , "Curse" , "Bad destiny" , "Mood of grim fate" .)