Deep gloom with motorway by south-east and railway (6)
I believe the answer is:
misery
'deep gloom' is the definition.
'misery' can be an answer for 'gloom' (thesaurus). I'm not sure about the 'deep' bit.
'motorway by south-east and railway' is the wordplay.
'motorway' becomes 'MI' (resembles M1, English motorway).
'by' means one lot of letters go next to another.
'south east' becomes 'SE' (abbreviation).
'and' says to put letters next to each other.
'railway' becomes 'ry' (abbreviation for railway).
'mi'+'se'+'ry'='MISERY'
'with' is the link.
Can you help me to learn more?
(Other definitions for misery that I've seen before include "Wretchedness, suffering" , "Feeling of great unhappiness" , "Intense unhappiness" , "Extreme unhappiness" , "Wretched state" .)