Deep irritation leads to depression? (5)
I believe the answer is:
ditch
'depression?' is the definition.
(I have seen 'long depression' mean 'ditch' so perhaps 'depression' could also mean 'ditch')
'deep irritation' is the wordplay.
'deep' becomes 'd' (this might be a standard abbreviation which I don't know about).
'irritation' becomes 'itch' (an itch irritates you).
'd'+'itch'='DITCH'
'leads to' acts as a link.
Can you help me to learn more?
(Other definitions for ditch that I've seen before include "Abandon - trench" , "long depression" , "Jettison" , "Get rid of; dug channel" , "Gully or furrow" .)