Deepest yellow around inflammation (4)
I believe the answer is:
stye
'inflammation' is the definition.
(I've seen this before)
'deepest yellow around' is the wordplay.
'around' indicates a hidden word.
'STYE' is hidden within 'deepest yellow'.
(Other definitions for stye that I've seen before include "Inflammation around the eye" , "Swelling near the eye" , "Red eye" , "pain for the observer" , "Eye complaint" .)