Defend orange, perhaps, where fruit caused loss (6,2,4)
I believe the answer is:
garden of eden
'where fruit caused loss' is the definition.
'defend orange perhaps' is the wordplay.
'perhaps' indicates an anagram.
'defend'+'orange'='defendorange'
'defendorange' with letters rearranged gives 'GARDEN OF EDEN'.
(Other definitions for garden of eden that I've seen before include "Idyllic haunt" , "Scene in Genesis" , "Genesis paradise" , "holy plot?" , "Biblical paradise" .)