Defoe's hero changing course (6)
I believe the answer is:
crusoe
'defoe's hero' is the definition.
(I've seen this in another clue)
'changing course' is the wordplay.
'changing' indicates anagramming the letters.
'course' with letters rearranged gives 'CRUSOE'.
(Other definitions for crusoe that I've seen before include "Daniel Defoe wrote ''Robinson . . . . . .''" , "Defoe's hero derived" , "See 11" , "Novel shipwrecked sailor" , "5 down [CASTAWAY]" .)