Departs from a city somewhere in South Africa (6)
I believe the answer is:
durban
'somewhere in south africa' is the definition.
The definition suggests a singular noun which matches the answer.
'departs from a city' is the wordplay.
'departs' becomes 'd' (common abbreviation e.g. train timetables).
'from' is a charade indicator (letters next to each other).
'a city' becomes 'urban' (I've seen this before).
'd'+'urban'='DURBAN'
Can you help me to learn more?
(Other definitions for durban that I've seen before include "in Natal" , "Rub Dan up the wrong way in S.Africa" , "South African city port" , "Southern port" , "Largest city in KwaZulu-Natal" .)