Depressed after opening analysis (9)
I believe the answer is:
breakdown
'analysis' is the definition.
(breakdown is a kind of analysis)
'depressed after opening' is the wordplay.
'depressed' becomes 'down' (synonyms).
'after' means one lot of letters go next to another.
'opening' becomes 'break' (I can't explain this - if you can you should believe this answer much more).
'down' put after 'break' is 'BREAKDOWN'.
Can you help me to learn more?
(Other definitions for breakdown that I've seen before include "Detailed analysis" , "Analysis < of separation" , "Stop running" , "Mechanical failure" , "As result of mental stress" .)