Depressed beauty entered building to pick up cocaine essentially (12)
I believe the answer is:
disheartened
'depressed' is the definition.
(thesaurus)
'beauty entered building to pick up cocaine essentially' is the wordplay.
I cannot quite see how this works, but
'beauty' could be 'dish' (slang term for an attractive person) and 'dish' is located in the answer.
This explanation may well be incorrect...
Can you help me to learn more?
(Other definitions for disheartened that I've seen before include "Upset; downcast" , "Having lost determination or confidence" , "Crestfallen" , "Discouraged" , "Despondent" .)