Depressed wife couldn't stomach ... (8)
I believe the answer is:
wretched
'depressed' is the definition.
Both the answer and definition are adjectives. Maybe there's a link between them I don't understand?
'wife couldn't stomach' is the wordplay.
'wife' becomes 'w' (abbreviation).
'couldn't stomach' becomes 'retched' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'w'+'retched'='WRETCHED'
Can you help me to learn more?
(Other definitions for wretched that I've seen before include "Sorry!" , "awful" , "misery" , "Very unhappy, miserable" , "Abject" .)