Depressing piece of misadventure (3)
I believe the answer is:
sad
'depressing' is the definition.
(similar in meaning)
'piece of misadventure' is the wordplay.
'piece of' says the answer is hidden in the clue.
'SAD' is hidden within 'misadventure'.
(Other definitions for sad that I've seen before include "grey" , "'Unhappy, sorry (3)'" , "Disconsolate" , "Dejected" , "Regrettable" .)