Depression associated with member facing endless shame (6)
I believe the answer is:
armpit
'depression' is the definition.
(thesaurus)
'member facing endless shame' is the wordplay.
'member' becomes 'arm' (member can mean a limb).
'facing' says to put letters next to each other.
'endless' means to remove the last letter.
'shame' becomes 'pity' (synonyms).
'pity' with its final letter removed is 'pit'.
'arm'+'pit'='ARMPIT'
'associated with' acts as a link.
(Other definitions for armpit that I've seen before include "evident given "hands up"!" , "Impart (anag.)" , "(In anatomy) the axilla" , "part of the body" , "Leave" .)