Crossword Genius

Deranged (8)

Ross

I think it could be either:

demented

unhinged

(Other definitions for demented that I've seen before include "Nutty" , "Out of one's mind" , "Wild, irrational" , "Deranged, crazy" , "Crazy, insane" .)

I've seen this clue in The Independent and The Mirror.
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