Des Moines's home (4)
I believe the answer is:
iowa
'des moines's home' is the definition.
(I've seen this in another clue)
This is all the clue.
(Other definitions for iowa that I've seen before include "part of US" , "'Hawkeye State'" , "part of United States" , "Midwest US state" , "US state, three vowels" .)