Design a Whirl centre nibble (4)
I believe the answer is:
gnaw
'nibble' is the definition.
(I've seen this before)
'design a whirl centre' is the wordplay.
'centre' indicates the answer is hidden within the clue (hidden in the middle of the letters).
'GNAW' is hidden in the letters of 'design a whirl'.
(Other definitions for gnaw that I've seen before include "Eat at" , "Prey on one's mind" , "Chew persistently at, say a bone" , "Chew steadily at" , "Chew away at" .)