Design alien world (6)
I believe the answer is:
planet
'world' is the definition.
(I know that world can be written as planet)
'design alien' is the wordplay.
'design' becomes 'plan' (synonyms).
'alien' becomes 'et' (extra terrestrial).
'plan'+'et'='PLANET'
(Other definitions for planet that I've seen before include "Large body orbiting sun" , "body in orbit" , "Venus, for example" , "Heavenly (or earthly!) body" , "Eg, a ruby" .)