Design tight pants - Amen! (4)
I believe the answer is:
mean
'design tight' is the definition.
'mean' can be an answer for 'design' (I've seen this before). I am not sure about the 'tight' bit.
'pants amen' is the wordplay.
'pants' indicates an anagram (UK informal term for 'nonsense' or 'rubbish').
'amen' with letters rearranged gives 'MEAN'.
Can you help me to learn more?
(Other definitions for mean that I've seen before include "Scrooge?" , "Petty" , "show" , "Intend - average - poor" , "Ungenerous" .)