Desire in Eden disastrous (4)
I believe the answer is:
need
'desire' is the definition.
(needing is a kind of desiring)
'eden disastrous' is the wordplay.
'disastrous' indicates anagramming the letters.
'eden' with letters rearranged gives 'NEED'.
'in' is the link.
(Other definitions for need that I've seen before include "Cry out for - prerequisite" , "state requiring relief" , "Want - poverty" , "destitute state" , "Exigency" .)