Desire of charming woman to go topless (4)
I believe the answer is:
itch
'desire' is the definition.
(itch is a kind of desire)
'charming woman to go topless' is the wordplay.
'charming woman' becomes 'witch'.
'to go topless' means to remove the first letter.
'witch' with its initial letter removed is 'ITCH'.
'of' is the link.
(Other definitions for itch that I've seen before include "Prickling" , "Restless longing" , "A strong restless desire" , "Uncomfortable feeling" , "Nagging wish" .)