Desire of topless enchantress! (4)
I believe the answer is:
itch
'desire' is the definition.
(I know that itch is a type of desire)
'topless enchantress' is the wordplay.
'topless' means to remove the first letter.
'enchantress' becomes 'witch' (synonyms).
'witch' with its initial letter taken off is 'ITCH'.
'of' is the link.
(Other definitions for itch that I've seen before include "Hunger, longing" , "Irritating pain" , "Long" , "Craving" , "that's irritating" .)