Desire sorceress, not wife (4)
I believe the answer is:
itch
'desire' is the definition.
(itch is a kind of desire)
'sorceress not wife' is the wordplay.
'sorceress' becomes 'witch' (I've seen this before).
'not' suggests deleting specific letters.
'wife' becomes 'w'.
'witch' with 'w' removed is 'ITCH'.
(Other definitions for itch that I've seen before include "are dying" , "A nagging desire" , "Niggling skin sensation" , "Irritating pain" , "Hunger, longing" .)