Desire subtle changes be removed? (4)
I believe the answer is:
lust
'desire' is the definition.
(lust is a kind of desire)
I don't understand the remainder of the clue.
(Other definitions for lust that I've seen before include "Depraved desire" , "Passionate desire" , "Libido" , "Lecherousness" , "Deadly sin of extreme passion" .)