Desmond Little's fate (7)
I believe the answer is:
destiny
'fate' is the definition.
(synonyms)
'desmond little's' is the wordplay.
'desmond' becomes 'des' (I've seen this in other clues).
'little' becomes 'tiny' (similar in meaning).
'des'+'tiny'='DESTINY'
(Other definitions for destiny that I've seen before include "Fortune" , "Kismet, fate" , "The future as arranged by fate" , "Lot" , "Ultimate fate" .)