Despair (7)
'despair' is the definition.
(I know that despond is a more specific form of the action despair)
This is all the clue.
(Other definitions for despond that I've seen before include "Its Slough, Bunyan" , "Become disheartened" .)
'despair' is the definition.
(synonyms)
This is the entire clue.
(Other definitions for lose hope that I've seen before include "Despair" , "Become pessimistic" .)