Desperate doctor has to leave hospital with nervous twitch (7)
I believe the answer is:
drastic
'desperate' is the definition.
(I've seen this before)
'doctor has to leave hospital with nervous twitch' is the wordplay.
'doctor' becomes 'dr' (abbreviation).
'to leave' indicates named letters should be taken away.
'hospital' becomes 'h' (abbreviation for hospital on maps).
'with' is a charade indicator (letters next to each other).
'nervous twitch' becomes 'tic' (involuntary twitch in the body).
'has' with 'h' removed is 'as'.
'dr'+'as'+'tic'='DRASTIC'
(Other definitions for drastic that I've seen before include "Desperate" , "Severe, radical (measures)" , "Harsh, severe" , "Radical, far-reaching" , "Draconian" .)