Despicable chap with female? Yes indeed! (6)
I believe the answer is:
rather
'yes indeed' is the definition.
(I've seen this in another clue)
'despicable chap with female?' is the wordplay.
'despicable chap' becomes 'rat' (I can't justify this - if you can you should believe this answer much more).
'with' says to put letters next to each other.
'female?' becomes 'her' (I've seen this in another clue).
'rat'+'her'='RATHER'
Can you help me to learn more?
(Other definitions for rather that I've seen before include "Pretty" , "On the contrary or to some extent" , "Quite, sort of" , "To a certain extent" , "On the contrary; more precisely" .)