Despite all that drawing, cartographers misdirected (4,2)
I believe the answer is:
even so
'despite' is the definition.
Both the answer and definition are adverbs. Maybe you can see an association between them that I can't see?
I don't understand how the remainder of the clue works.
Can you help me to learn more?
(Other definitions for even so that I've seen before include "Notwithstanding" , "'Despite, still (4,2)'" , "Just the same, though that may be the case" , "'Nonetheless (4,2)'" , "yet" .)