Despot’s extremely timely tirade (6)
I believe the answer is:
tyrant
'despot's' is the definition.
('tyrant' can be a synonym of 'despot')
'extremely timely tirade' is the wordplay.
'extremely' means to remove the middle letters.
'tirade' becomes 'rant' (I've seen this before).
'timely' with its middle taken out is 'ty'.
'ty'+'rant'='TYRANT'
(Other definitions for tyrant that I've seen before include "Oppressive and cruel ruler" , "Person dictating" , "Autocrat - bully" , "big bully" , "Totalitarian" .)