Destined to be tipsily daft around closing time (5)
I believe the answer is:
fated
'destined' is the definition.
(someone fated to do something is destined to it)
'tipsily daft around closing time' is the wordplay.
'tipsily' indicates an anagram (in a drunk or tipsy way).
'around' says to take the centre.
'closing time' becomes 'ted' (I can't explain this - if you can you should believe this answer much more).
The central letters of 'daft' are 'af'.
'af' with letters rearranged gives 'fa'.
'fa'+'ted'='FATED'
'to be' is the link.
Can you help me to learn more?
(Other definitions for fated that I've seen before include "Doomed or destined" , "Suffering a lot" , "Destined - inevitable" , "Destined, foreordained (5)" , "Predestined" .)