Destroy; animation; strike; hurry, primarily (4)
I believe the answer is:
dash
I believe this clue is a quadruple definition!!
'destroy' is the first definition.
(thesaurus)
'animation' is the second definition.
(thesaurus)
'strike' is the third definition.
(thesaurus)
'hurry primarily' is the fourth definition.
'dash' can be an answer for 'hurry' (dashing is a kind of hurrying). I am not certain of the 'primarily' bit.
(Other definitions for dash that I've seen before include "sudden advance" , "gratuity" , "Rush - elan" , "zip" , "Shatter - run" .)